Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission

The paradoxical psychological effects of lysergic acid diethylamide (LSD).

BACKGROUND Lysergic acid diethylamide (LSD) is a potent serotonergic hallucinogen or psychedelic that modulates consciousness in a marked and novel way. This study sought to examine the acute and mid-term psychological effects of LSD in a controlled study. METHOD A total of 20 healthy volunteers participated in this within-subjects study. Participants received LSD (75 µg, intravenously) on on...

Tricyclic antidepressant drugs: attenuation of excitatory effects of d-lysergic acid diethylamide (LSD) on acoustic startle response.

At a dose of 5 mg/kg, the tricyclic antidepressant drugs chlorimlpramine (ClMI), desipramine (DMI), Imipramlne (IMI), ii and chlordeslpramine (C-DMI) all blocked the excitatory effects of a low dose (30 _g/kg) of LSD on the acoustic startle response in the rat. Over a dose range from I-5 " , mg/kg, CIMI and DMI were about equally potent in blocking the LSD effect, despite the fact that both dru...

D-lysergic acid diethylamide (LSD-25): a survey of the literature.

RNA synthesis in isolated brian nuclei after administration of d-lysergic acid diethylamide (LSD) in vivo.

RNA synthesis in isolated brain nuclei was analyzed 2.5 hr after the intravenous administration of d-lysergic acid diethylamide (LSD) to young rabbits. The drug stimulated transcription by 54% in brain stem nuclei and by 13% in cerebral hemisphere nuclei expressed over saline controls. Both nucleoplasmic and nucleolar RNA synthesis were increased. The main activity in the isolated nuclei assay ...

Placebo reactions in a study of lysergic acid diethylamide (LSD-25).